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Antihistamines and steroid medication Your GP may suggest taking antihistamines to reduce swelling when it occurs. Antihistamines work by blocking the effects of histamine, one of the chemicals responsible for the swelling. Some types can be bought in pharmacies and supermarkets without a prescription. Some antihistamines can make you feel drowsy, so it’s best to take non-drowsy medications such as cetirizine and loratadine if your symptoms occur during the day. Some antihistamines can androgel testosterone gel price you feel drowsy. Avoid driving, drinking alcohol or operating dangerous machinery if you experience this.