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Norethisterone was discovered in 1951 and was one of the first progestins to be developed. Another medical use of norethisterone is to alleviate endometriosis related pain. In most clinical studies of norethisterone for contraception or menopausal hormone therapy, the drug has been combined with an estrogen, and for this reason, it is difficult to determine which of the side effects were caused by norethisterone and which of them were caused by estrogen in such research. Other side effects have included periodic abdominal bloating and breast tenderness, both of which are thought to be due to water retention and can be relieved with diuretics. There has been no association with weight gain, and blood pressure, blood clotting, and glucose tolerance have all remained normal. However, a decrease in HDL cholesterol has been observed. The sebaceous glands are highly androgen-sensitive and their size and activity are potential markers of androgenic effect. High-dosage norethisterone has been used to suppress menstruation in women with severe intellectual disability who were incapable of handling their own menses.

There have been no reports of serious side effects with overdose of norethisterone, even in small children. As such, overdose usually does not androgel testosterone gel price treatment. 5α-Reductase plays an important role in the metabolism of norethisterone, and 5α-reductase inhibitors such as finasteride and dutasteride can inhibit its metabolism. Norethisterone is a potent progestogen and a weak androgen and estrogen. Norethisterone displays 8 times higher progestational activity than progesterone. AR, and in accordance, is weakly androgenic.