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It stimulates blood fibrinolysis and has been evaluated for the treatment of the more advanced skin changes in venous disease such as lipodermatosclerosis. Several randomized trials noted improvement in the area of lipodermatosclerosis, reduced skin thickness, and possibly faster ulcer healing rates with stanozolol. Stanozolol is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters. Chemical syntheses of stanozolol have been published. Stanozolol is subject to extensive hepatic biotransformation by a variety of enzymatic pathways. Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry. In 1962, Stanozolol was brought to market in the US by Winthrop under the tradename “Winstrol” and in Europe by Winthrop’s partner, Bayer, under the name “Stromba”. Also in 1962, the Kefauver Harris Amendment was passed, amending the Federal Food, Drug, and Cosmetic Act to require drug manufacturers to provide proof of the effectiveness of their drugs before approval.
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