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It stimulates blood fibrinolysis and has been evaluated for the treatment of the more advanced skin changes in venous disease such as lipodermatosclerosis. Several randomized trials noted improvement in the area of lipodermatosclerosis, reduced skin thickness, and possibly faster ulcer healing rates with stanozolol. Stanozolol is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters. Chemical syntheses of stanozolol have been published. Stanozolol is subject to extensive hepatic biotransformation by a variety of enzymatic pathways.
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Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry. In 1962, Stanozolol was brought to market in the US by Winthrop under the tradename “Winstrol” and in Europe by Winthrop’s partner, Bayer, under the name “Stromba”. Also in 1962, the Kefauver Harris Amendment was passed, amending the Federal Food, Drug, and Cosmetic Act to require drug manufacturers to provide proof of the effectiveness of their drugs before approval. FDA allowed the drug to be continued to be marketed, since there was an unmet need for drugs for osteoporosis and pituitary dwarfism, but Sterling was required to submit more data. In 1980 the FDA removed the dwarfism indication from the label for stanozolol since human growth hormone drugs had come on the market, and mandated that the label for stanozolol and other steroids say: “As adjunctive therapy in senile and postmenopausal osteoporosis.
AAS are without value as primary therapy but may be buy Prime Pharmaceuticals steroids value as adjunctive therapy. In April 1984, the FDA announced that the data was not sufficient, and withdrew the marketing authority for stanozolol for senile and postmenopausal osteoporosis and for raising hemoglobin levels in aplastic anemia. Sanofi had stanzolol manufactured in the US by Searle, which stopped making the drug in October 2002. Even with no drug in production, Sanofi sold the stanozolol business to Ovation Pharmaceuticals in 2003, along with the two other drugs. 2014 no other company is marketing stanozolol as a pharmaceutical drug in the US but it can be obtained via a compounding pharmacy.